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Frontiers in Immunology , 12 , 653025

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This study, through comparison of IBD and SI-NET molecular profiles, aims to uncover 1) different relationships between SI-NET and the two different IBD phenotypes, 2) pro-inflammatory genes and proteins shared by IBD and SI-NET, particularly in SI-NET pathogenesis and tumor microenvironment, 3) diagnostic biomarkers and therapeutic targets in both diseases, and 4) possible biological pathways and molecular mechanisms that are both expressed in IBD highly immune-active and SI-NET immunosuppressive environment